Electron Transport Chain Explained (Complex 1-4, Q Cycle, Reduction Potential) | Clip

Welcome to Science With Tal!

In this video, we will cover how the electron transport chain functions by analyzing complex 1 to 4 and all the components in between that make it happen (cytochrome molecules, NADH, FADH2, CoQ-CoQH2, FMN, etc.). We will also discuss some more general topics such as the reduction potential that are super important to understand how the ETC operates.

Here is the link for the full discussion:
   • Carbohydrate & Fat Metabolism Explained | ...  

You can consult the PDF of the metabolic map here: https://drive.google.com/file/d/1_NKQ...

To improve the quality of my content, I highly value the feedback from the viewer so do not hesitate to give any feedback in the comment section.

TIMESTAMPS

0:00 Introduction
0:18 Overview of the ETC & oxidative phosphorylation
4:46 Reduction potential & thermodynamics
7:21 Complex 1
12:30 Complex 2
15:50 Complex 3 & Q cycle
21:00 Complex 4
22:51 Recap
24:18 Conclusion

RESOURCES

Here is a list of the resources that I’ve used to produce this video. (Author(s): title resource)

Textbooks
1. Lodish: Molecular Cell Biology (9th ed., 2022)
2. Voet: Fundamentals of Biochemistry (5th ed., 2016)

Scientific articles
3. Webb: Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations (2015)
https://pubmed.ncbi.nlm.nih.gov/25985...

4. Crocher: Crystal structure of heart 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase (PFKFB2) and the inhibitory influence of citrate on substrate binding (2017)
https://pubmed.ncbi.nlm.nih.gov/27802...

5. Revel: Electron microscopy of glycogen (1964)
https://pubmed.ncbi.nlm.nih.gov/14187...

6. McCommis: Mitochondrial pyruvate transport: a historical perspective and future research directions (2015)
https://www.ncbi.nlm.nih.gov/pmc/arti....

7. Škerlová: Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion (2021)
https://pubmed.ncbi.nlm.nih.gov/34489...

8. Denton: The hormonal regulation of pyruvate dehydrogenase complex (1996)
https://pubmed.ncbi.nlm.nih.gov/8869747/

9. Baradaran: Crystal structure of the entire respiratory complex I (2013)
https://www.ncbi.nlm.nih.gov/pmc/arti...

10. Maier: The crystal structure of a mammalian fatty acid synthase (2008)
https://pubmed.ncbi.nlm.nih.gov/18772...

11. Saltiel: Insulin signaling in health and disease (2021)
https://pubmed.ncbi.nlm.nih.gov/33393...

12. Rahman: Role of Insulin in Health and Disease: An Update (2021)
https://pubmed.ncbi.nlm.nih.gov/34203...

13. Gao: α-cell electrophysiology and the regulation of glucagon secretion (2023)
https://pubmed.ncbi.nlm.nih.gov/37159...

CREDITS

Writing: Tal Klimenko
Voice: Tal Klimenko
Animations: Tal Klimenko
Drawings: Tal Klimenko
Editing: Tal Klimenko
Introductory jingle: Thierry Du Sablond
Conclusion music: lukrembo - sunflower (   • lukrembo - sunflower (no copyright music)  )