Does Insulin cause Atherosclerosis?

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0:00 - Introduction
0:51 - Insulin - Plaque Forming?
2:15 - Dying Quickly or Dying Slowly? You Choose.
5:02 - Any Scientific Merit?
6:27 - Normal Pathway: Akt
7:23 - Cell Migration, Abnormal Pathway: ERK
8:01 - Separating Insulin from Insulin Resistance
12:00 - Unique Cellular Reaction to Insulin Resistance
13:07 - Main Points

References
[A] Bornfeldt KE, Tabas I. Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab. 2011;14(5):575-585. doi:10.1016/j.cmet.2011.07.015

[B] Lightell DJ Jr, Moss SC, Woods TC. Loss of canonical insulin signaling accelerates vascular smooth muscle cell proliferation and migration through changes in p27Kip1 regulation. Endocrinology. 2011;152(2):651-658. doi:10.1210/en.2010-0722

[C] Rask-Madsen C, Buonomo E, Li Q, et al. Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol. 2012;32(5):1124-1131. doi:10.1161/ATVBAHA.111.239558

[D] Del Prato S, Leonetti F, Simonson DC, Sheehan P, Matsuda M, DeFronzo RA. Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia. 1994;37(10):1025-1035. doi:10.1007/BF00400466

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#insulinresistance #diabetesawareness