Dr. Thomas Brunner on the ESOPEC Trial and Treatment Strategies for Esophageal Cancer | ESTRO 2025

At ESTRO 2025, Dr. Thomas Brunner, radiation oncologist from Graz, Austria, shares expert insights on the landmark ESOPEC trial, which directly compared two major treatment strategies for esophageal and gastroesophageal junction adenocarcinoma:

Perioperative chemotherapy (FLOT regimen)

Neoadjuvant chemoradiation (CROSS regimen)

📌 Interview highlights:
✅ Rationale for the head-to-head comparison between FLOT and CROSS
✅ Trial setup, funding hurdles, and primary endpoints including overall survival
✅ Preview of upcoming ASCO 2025 data on relapse patterns and site-specific responses
✅ Discussion on integrating durvalumab (CheckMate 577) and systemic therapy
✅ Future research on combining radiation with immunotherapy and advancing organ preservation strategies

About ESTRO 2025

ESTRO 2025 is the leading global event for radiation oncology professionals, hosted by the European Society for Radiotherapy and Oncology (ESTRO). This congress, held from May 2 to 6, 2025, at the Messe Wien Exhibition & Congress Center in Vienna, Austria, brings together experts from around the world to showcase cutting-edge research, discuss the latest advancements in radiotherapy, and explore future trends in oncology.

#ESTRO2025 #ESOPECTrial #EsophagealCancer #FLOT #CROSSRegime #Durvalumab #RadiationOncology #GIOncology

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