Biochemistry | Enzyme Inhibition

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Ninja Nerds!
In this lecture, Professor Zach Murphy presents a clear and comprehensive breakdown of Enzyme Inhibition, focusing on the major types of inhibition that regulate enzymatic activity and alter reaction kinetics. Building on the Michaelis-Menten framework, this lecture helps you understand how inhibitors affect Km, Vmax, and overall enzyme efficiency.

We begin by distinguishing between reversible and irreversible inhibition, then focus on the three main types of reversible inhibition: competitive, noncompetitive, and uncompetitive. You’ll learn how each type uniquely impacts enzyme-substrate binding, active site access, and catalytic function—and how these changes are visualized through Michaelis-Menten and Lineweaver-Burk plots.

This lecture also explores the clinical relevance of enzyme inhibition, such as how competitive inhibitors like statins and ACE inhibitors function, and how irreversible inhibitors are used in pharmacology and toxicology. Special emphasis is placed on recognizing kinetic patterns and interpreting graph-based enzyme data.

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