Does Metformin Unlock a Longer Lifespan? What We Know So Far.

Timestamps:
[00:37] Why is metformin of interest in longevity?
[01:46]What is Metformin
[02:36] How Metformin Works
[07:40] The Metformin Longevity Evidence In Animal Studies
[10:55] Human Evidence
[13:20] How safe is metformin?
[14:04] Is there a known longevity dose?

Metformin is a popular consideration for those of us looking to manage and moderate the cellular process of aging and all the unpleasant consequences it brings. Certainly, it has been of significant benefit to a great number of people with type 2 diabetes, but the question today is whether it is life-extending in those of us without this condition.

In this video, I cover:
Why metformin is of interest in longevity
What meformin is
How metformin works (or, at least, some of its main mechanisms of action in the human body)
What evidence we have that it extends the lives of lab animals
What relevant human evidence we have
How safe it appears to be
Whether we should be taking it (Alas, the answer is a personal one so I refrain from committing too firmly to this promising sounding medication)

Studies referenced in the video:

TAME study link https://www.afar.org/tame-trial
How Metformin works https://pmc.ncbi.nlm.nih.gov/articles....

Worm study showing it extended life only in worms with E. coli in their gastrointestinal tract https://pmc.ncbi.nlm.nih.gov/articles...

Metformin life-extending study of mice https://pmc.ncbi.nlm.nih.gov/articles...
Metformin dose-dependent effect on lifespan in mice https://pmc.ncbi.nlm.nih.gov/articles...

Mouse lifespans vs duration of metformin therapy https://pmc.ncbi.nlm.nih.gov/articles...

Metformin Mechanisms of Action paper https://pmc.ncbi.nlm.nih.gov/articles...

Metformin inducing GLP-1 secretion in humans study https://pmc.ncbi.nlm.nih.gov/articles...

Taiwanese study of dementia risk in people with T2DM either on metformin or not https://journals.sagepub.com/doi/10.3...

The 2014 paper that began it all - https://dom-pubs.pericles-prod.litera...

2017 systematic review https://www.sciencedirect.com/science...

2021 21-year study into metformin’s effect on all-cause mortality in 3,234 adults starting the programme as pre-diabetics https://diabetesjournals.org/care/art...

** All the information contained in this video is not intended nor implied to constitute professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general informational purposes only and does not replace a consultation with your own doctor/health professional **