The Binding of Isaac | Today's Curated Daily Run (Thanksgiving) 27th Nov 2025

THANKSGIVING curated run! (Magdalene starts with Cupid's Arrow and the bosses all drop Rotten Meat)

Goal: Magdalene vs. Mega Satan [Normal Difficulty]
Spiciest Stuff: Athame, Brittle Bones, Satanic Bible, A Lump of Coal, Eye of the Occult, Pentagram, 20/20, Capricorn, Haemolacria,
Transformations: Conjoined

It's Magdalene's second run of the month.

Interestingly, the Satanic Bible counters one of the main facets of the curation; switching the Rotten Meats for devilish alternatives! This was an advantage but didn't result in that strong of a build. The Tear Rate was strong but the DMG was lacking...

Left myself very short on time but fluked into Boss Rush.
It was slow going inside too. Athame did occasionally wreck through some waves though.

Boss Rush took so long I thought Hush was a pipe dream, but I somehow managed to find both Womb bosses pretty much straight away so fluked in again!
Athame was, again, the star item for this battle. This would've taken ages too without it.

Gained Conjoined and Haemolacria by Mega Satan and the build finally felt competitive. Easy in the end.

Brittle Bones and the Satanic Bible meant HP wasn't a concern.
Defence came from Halo of Flies and later, Spider Bite.

Took far too long to get going. Mid.

Best of luck!

Fun rating: ⭐⭐⭐

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