What Actually Works for Cellular Aging | Dr Sundeep Khosla

Dr. Khosler provides evidence-based recommendations for managing senescent cells today, explaining why popular supplements may not be the answer and which FDA-approved drugs show promise for specific conditions.
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Dr. Sundeep Khosler offers practical, science-based guidance on managing senescent cell burden without experimental interventions. He explains why he doesn't recommend dasatinib and quercetin outside clinical trials despite their use in research, and why fisetin lacks sufficient evidence. Instead, he emphasizes lifestyle interventions with proven effects: moderate exercise, modest caloric restriction, and avoiding smoking. For those with specific conditions, he discusses FDA-approved medications that may impact senescent cells as a secondary benefit—metformin for pre-diabetes, zoledronic acid for osteoporosis, and the complex question of GLP-1 receptor agonists. Dr. Khosler also addresses the absence of specific symptoms indicating high senescent cell burden and explains why current commercial testing options remain limited. This practical discussion bridges the gap between cutting-edge research and actionable steps available today.

📚 Chapters
0:00 - Should You Take Senolytics Now?
1:06 - Why Dasatinib Isn't Ready
2:46 - The Quercetin Question
3:46 - Lifestyle Interventions That Work
4:33 - Exercise and Caloric Restriction
5:41 - Metformin's Senomorphic Effects
7:18 - Zoledronic Acid for Bone Health
8:04 - The GLP-1 Agonist Debate
9:54 - Are There Warning Symptoms?
11:41 - No FDA-Approved Senolytics Yet
12:53 - The Personalized Medicine Twist
13:59 - Looking Ahead to Future Trials

🌐Links in this video
Dr Khosla's page at the Mayo Clinic https://www.mayo.edu/research/faculty...
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial
https://pubmed.ncbi.nlm.nih.gov/38956...

#Longevity #Senolytics #healthyaging