Exosomes Webinar 28 - Science of Exosomes

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Webinar #28: Exosome Science 101—What We Know (And Don't Know)
Exosome science is only 12 years old. Before that, researchers were throwing away the most important biological messengers without even knowing it. Why? Because you can only find what you're looking for.

Dr. Ed Park explores the fascinating history of exosome discovery, the machinery that creates them, how they're identified, and the uncomfortable truth: we barely understand what they do.

The Discovery Problem:
Scientists were obsessed with proteins (visible) and cells (visible), but exosomes at 100 nanometers fell into an invisible gap. Nobody was looking. Nobody was funding it. So for decades, exosomes were discarded as cellular junk.

What We Know:
Exosomes are 100-nanometer phospholipid spheres (same tech as COVID vaccines)
Created intentionally by cells via multivesicular bodies (MVBs)
Contain mRNA, microRNA, proteins, and lipids
Identified by tetraspanins (CD9, CD63, CD81)
Mesenchymal stem cell exosomes are anti-inflammatory and regenerative
Isolated via ultracentrifugation or micro-filter cylinders

What We Don't Know:
How cells decide what to package into exosomes
Why exosomes from cancer patients can transform healthy cells
Whether bad exosomes cause disease or result from it
The full symphony of proteins and microRNAs working together
How to predict which exosomes will help which conditions

The Music Analogy:
Studying exosomes with proteomics and genomics is like analyzing a song by listing its individual notes. You can identify F-sharp and C-sharp, but you miss the melody, harmony, genre, emotion, and context. We're taking snapshots of dynamic systems we don't have the tools to understand.

Can You Patent Exosomes?
The Supreme Court ruled you can't patent the BRCA gene (natural DNA). But synthetic DNA (like mRNA vaccines) can be patented. Living cells? Still unclear. This matters for FDA approval—living systems are dynamic, not reproducible like pharmaceuticals.

The Pac-Man Principle:
What you know is small. What you don't know is bigger. What you don't even know you don't know is infinite. As exosome science expands, our ignorance expands faster.

Bottom Line:
We're helping patients with something we barely understand. That's both humbling and exciting. Next week: the history of how Dr. Park got involved with exosomes.

Books by Dr. Park:
"Exosomes: Songs of Healing" | https://tinyurl.com/exohbook
"The Telomere Miracle" | https://tinyurl.com/ttmbook
"Telomere Timebombs" | https://tinyurl.com/ttbbook

More content: rechargebiomedical.com | YouTube: drpark65

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