Understanding Systemic Sclerosis (Scleroderma)

Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune disease characterized by vascular dysfunction, immune system activation, and progressive tissue fibrosis. In this episode of Medical Foundations, we explore the underlying mechanisms of systemic sclerosis, from genetic susceptibility and environmental triggers to immune-mediated fibrosis and organ damage.

We discuss how systemic sclerosis affects multiple organs, including the skin, lungs, heart, kidneys, and gastrointestinal tract, and why pulmonary and cardiac complications remain the leading causes of mortality. The episode also covers current clinical approaches to diagnosis, monitoring, and treatment, including immunosuppressive therapies such as methotrexate and mycophenolate mofetil, as well as targeted management of Raynaud phenomenon and interstitial lung disease.

Although the exact causes of systemic sclerosis are not fully understood, early recognition and organ-based management are critical to slowing disease progression and improving outcomes. This episode provides a clear, evidence-based overview for students, clinicians, and anyone interested in understanding the foundations of autoimmune connective tissue diseases.

💡 Note: This episode was created using Google’s NotebookLM. The views expressed do not necessarily reflect those of the authors or their institutions.

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