Epi3: Scaling Up Sample Lysis: How Upstream Automation Keeps High-Throughput Studies on Track

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High-throughput studies fall apart fast if your sample lysis isn’t rock solid.

In this episode of Omni Pod, I (Gabby Ryan, Sr. Application Scientist at Omni International, a Revvity brand) sit down with Bill Schick (Fractional CMO, Omni International) to talk about pre-sample analysis and scaling up sample lysis for high-throughput workflows with upstream automation—so your data volume goes up without your data quality falling off a cliff.

See how labs are scaling sample lysis with Omni’s LH 96 automated sample prep platform:
https://omni-inc.com/lh-96-automated-...

We dig into what actually breaks when you try to scale from dozens of samples to hundreds or thousands: inconsistent lysis, edge effects in plates, variable hands on the bench, and methods that weren’t built for throughput in the first place. From plate-based workflows to tube-based prep, we break down how to think about pre-sample analysis, bead/media choice, speed, and timing before you even touch a pipette—so automation amplifies good methods instead of automating bad ones.

What you’ll learn:

Why pre-sample analysis is the missing step in most “scale-up” plans

How to decide if your current lysis method will survive going high-throughput (or quietly wreck your assay)

Practical ways to standardize lysis conditions across plates, runs, and operators

How upstream automation can de-risk large studies by tightening variability at the very front of the workflow

Where automated bead-mill homogenization fits vs manual or semi-manual approaches

Real-world examples of moving from low-throughput methods to automated sample lysis without rebuilding your entire assay

How to think about plate maps, controls, and QC checks when you’re running 96-well or higher-density formats

A simple framework for deciding when it’s time to move from “good enough” manual prep to an automated platform

Who this is for:
Preclinical and translational researchers, lab managers, and assay development teams running (or planning) high-throughput studies—screening, omics, biomarker discovery, or large cohort work—who are worried that their current sample lysis approach can’t scale without trashing reproducibility.
Subscribe for more practical, lab-tested conversations on building faster, cleaner, and more repeatable workflows at the front end of preclinical research—and drop your questions in the comments so we can dig into your specific sample-lysis and automation challenges next.

https://omni-inc.com
https://omni-inc.com/bead-ruptor-elite
https://omni-inc.com/lh-96-automated-...

Keywords: sample lysis, sample preparation, high-throughput studies, upstream automation, LH 96, bead mill homogenization, plate-based workflows, assay development, pre-sample analysis, protocol standardization, lab automation, Omni International

#SamplePrep #SampleLysis #LabAutomation #HighThroughput #Homogenization #BeadMilling #LabEfficiency #DataIntegrity #OmniInternational #Revvity #LH96