18. Balancing Methylation: A Game-Changer for Mental Health, Perimenopause & Menopause

In this episode of The Histamine Well, host Joanne speaks with Amanda Bradshaw, co-founder of Mood Sense, to explore the critical role methylation plays in mood, mental health, and hormonal transitions like perimenopause. Joanne shares her clinical insights and surprising test results showing that some patients assumed to be under-methylators were actually over-methylating—changing the course of their treatment.

Amanda opens up about her personal health journey through perimenopause and how balancing her methylation significantly improved symptoms like mood swings and hot flushes. Together, they unpack how methylation imbalances can impact not just mental health, but also relationships, family dynamics, and even parenting—especially in neurodivergent households.

Listeners will also gain practical guidance on how the Mood Sense test works, and how diet, lifestyle, and targeted supplements can help restore balance and support emotional resilience.

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Time stamps:

00:00 Introduction and Episode Overview
00:19 Meet Amanda Bradshaw: Co-founder of Mood Sense
01:26 Understanding Methylation in Perimenopause
02:21 Amanda's Personal Journey with Methylation
05:27 The Impact of Methylation on Mood and Relationships
09:21 Balancing Methylation: Tools and Techniques
12:19 Methylation and Mental Health: Amanda's Experience
23:11 The Mood Sense Test: How It Works
32:21 Exploring Overwhelm and Boundaries
33:29 Balancing Relationships Through Methylation
35:40 A Personal Story of Methylation Differences
37:54 Family Communication and Methylation
40:51 Addressing Children's Health Issues with Methylation
46:29 The Mood Sense Test and Its Impact
51:03 Balancing Methylation in Daily Life
58:35 Concluding Thoughts and Resources

#methylation #mentalhealth #perimenopause #menopause