Prostate Cancer Explained | Anatomy, Pathogenesis, Gleason Score, TNM Staging& management Med 1Pager

Welcome to Med 1Pager! My name is Benjamin, and today we break down Prostate Cancer — one of the most important topics in urology and oncology.
This full lecture covers everything from anatomy and pathogenesis to diagnosis, Gleason grading, TNM staging, complications, prognosis, and management — explained in a clear, concise, and exam-focused way.

📘 Topics Covered:
00:00 Introduction
00:46 Anatomy of the prostate (zones, capsule, venous plexus, fascia of Denon Villiers)
01:59 Etiology & Pathogenesis (androgens, BRCA2, PTEN, TMPRSS2-ERG fusion, inflammation)
05:16 Clinical Features of Prostate Cancer (LUTS, bone pain, metastasis, constitutional symptoms)
07:41 Screening & Early Detection (PSA levels, PSA density, PSA velocity, DRE, risk groups)
11:04 Diagnosis of Prostate Cancer (imaging, PI-RADS, biopsy, histology)
13:20 Gleason Grading & ISUP Grouping (patterns, scoring, prognosis)
16:52 TNM Staging of Prostate Cancer (T1–T4, N, M classification)
17:48 Complications of Prostate Cancer (metastasis, obstruction, anemia, therapy-related effects)
18:32 Prognosis (localized vs advanced disease survival rates)
19:27 Prevention of Prostate Cancer (diet, lifestyle, finasteride, lycopene, omega-3)
20:10 Management of Prostate Cancer (surveillance, surgery, radiotherapy, ADT, palliative care)

💡 Highlights:

Understand how androgen dependence drives early tumor growth

Learn how Gleason scoring (3+4 vs 4+3) affects prognosis

Simplified PSA interpretation, TNM staging, and treatment algorithms

Clear explanation of spread routes, including vertebral metastasis via Batson’s plexus

📈 Ideal for medical students, interns, clinicians, and postgraduate candidates revising urology and oncology.
Don’t forget to watch the BPH video for comparison — it covers key anatomy and pathophysiology links!

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