May 20,2025 MUHC Medical Grand Rounds by Sundeep Khosla MD, Mayo Clinic College of Medicine and Sc.

Title: Targeting Cellular Senescence to Treat Osteoporosis
Speaker: Sundeep Khosla M.D.,
Dr. Francis Chucker and Nathan Landow Research Professor Mayo Foundation Distinguished Investigator Mayo Clinic College of Medicine and Science, Consultant, Division of Endocrinology, Diabetes, Metabolism, Nutrition, Department of Internal Medicine, Joint Appointment as Consultant, Section of Geriatric Medicine and Gerontology, Department of Internal Medicine

Educational objectives
•Understand cellular senescence as an aging mechanism
•Define interventions targeting cellular senescence that improve multiple age-related morbidities

Biosketch of Sundeep Khosla M.D., Dr. Francis Chucker and Nathan Landow Research Professor Mayo Foundation Distinguished Investigator Mayo Clinic College of Medicine and Science:
Sundeep Khosla, M.D., is an endocrinologist who studies age-related bone loss. Through his Osteoporosis and Bone Biology Laboratory, Dr. Khosla examines how fundamental aging mechanisms in bone, especially cellular senescence, lead to increased skeletal fragility. Dr. Khosla also studies how the aging skeleton interacts with other tissues, including muscle, fat, and brain tissue. Dr. Khosla's lab has developed several genetic models for the clearance of senescent cells globally and in a tissue-specific manner. Dr. Khosla's lab has used single-cell proteomic and transcriptomic tools to identify senescent cells in vivo in the bone microenvironment and to determine how these cells interact with immune cells. Dr. Khosla also studies the role of senescent cells in tissue repair, specifically fracture healing. Focus areas Mechanisms of age-related bone loss. Cellular senescence in bone and other tissues. Role of cellular senescence in tissue repair. Interactions of aging bone and immune cells. Significance to patient care Dr. Khosla's work has the potential to significantly impact how people with osteoporosis are diagnosed and treated. He defines the pathways that lead to bone loss with aging. These pathways may identify new molecular targets for medicines to reverse osteoporosis. Additionally, his studies on fracture healing may lead to new approaches to prevent fracture nonunions.