Immunology (16)| Lectins and Formyl Peptide Receptor 1(FPR1) | Cellular Receptors of Innate Immunity
Автор: Mahmoud Abdelwahed Diab_محمود عبدالواحد دياب
Загружено: 2025-12-14
Просмотров: 4
In Immunology (16), this lecture focuses on lectins and Formyl Peptide Receptor 1 (FPR1) as key cellular receptors of the innate immune system. These receptors play essential roles in the early detection of pathogens and in directing immune cells toward sites of infection and tissue damage.
Topics covered in this lecture include:
Overview of cellular receptors in innate immunity
Lectin receptors:
Definition and general characteristics
Recognition of carbohydrate patterns on microbial surfaces
Role of C-type lectin receptors (CLRs) in pathogen binding, phagocytosis, and immune activation
Examples such as mannose receptor and dectin-1
Formyl Peptide Receptor 1 (FPR1):
Structure and classification as a G protein–coupled receptor (GPCR)
Recognition of N-formylated peptides derived from bacteria and mitochondria
Role in neutrophil and macrophage chemotaxis
Contribution to phagocyte activation and microbial killing
Downstream signaling pathways triggered by lectins and FPR1
Functional outcomes:
Cell migration to inflammatory sites
Phagocytosis and pathogen clearance
Amplification of innate immune responses
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