DNA Replication | USMLE Step 1 Biochemistry (First Aid)

Master the high-yield concepts of DNA Replication exactly as they appear in First Aid for the USMLE Step 1! In this video, we break down the molecular mechanism of replication, the specific functions of key enzymes, and the crucial clinical correlates you need to know for the exam.
We cover the differences between prokaryotic and eukaryotic replication and highlight the drug targets associated with these pathways (e.g., Topoisomerase inhibitors).
📝 Topics Covered in This Video:
Origin of Replication: Consensus sequences and AT-rich regions.
Unwinding the Strands: The role of Helicase and Single-Stranded Binding Proteins.
Relieving Strain: Topoisomerase II (DNA Gyrase) vs. Topoisomerase I and their pharmacological inhibitors (Fluoroquinolones, Etoposide).
Synthesis: Primase, DNA Polymerase III (proofreading), and DNA Polymerase I (primer removal).
Joining the Fragments: The function of DNA Ligase on Okazaki fragments.
Telomerase: Its role in eukaryotes and implications for aging/cancer.
Clinical Correlates: Diseases and drugs related to replication errors.
📚 Source Material:
First Aid for the USMLE Step 1 (Biochemistry Section)
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