Most Longevity Experts Don't Tell You This About Aging | 56 - Longevity Science #8

Subscribe to our channel:    / @optispan  

Related episodes:

Biological Age & what it REALLY means:    • Biological Age & what it REALLY means | 9 ...  

The Surprising Way Body Size Relates to Lifespan:    • The Surprising Way Body Size Relates to Li...  

The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21:    • The Benefits of Protein Restriction, How P...  

An introduction to the study of RAPAMYCIN:    • An introduction to the study of RAPAMYCIN ...  

Depending on how you look at them, aging genes are genes whose expression changes in a predictable with age or genes that influence an organism's lifespan by affecting various biological processes associated with aging. Research on aging genes not only deepens our understanding of the biological aging process, but also opens up potential avenues for developing therapies aimed at extending healthy human lifespan. By targeting these genes, scientists hope to delay the onset of age-related diseases such as Alzheimer's disease, cardiovascular disease, and cancer, ultimately promoting a longer and healthier life.

In this episode, Matt discusses several ways we can identify and categorize aging genes. He talks about how genes can serve as predictive signatures of chronological or biological age, potential conserved genetic regulators of longevity, and how unbiased genetic screens can still be biased. He also provides his unique perspective on aging genes in humans and the potential to optimize longevity through genetic modulation.

0:00 Introduction
1:05 Definition 1 of an aging gene
2:23 Definition 2 of an aging gene
2:58 Genes as biomarkers of aging, biological age clocks
7:07 Nuances of definition 2
9:25 What we should be focusing on
10:59 The daf-2 gene and lifespan
12:41 The sir2 gene and lifespan
13:31 FGF21 and lifespan
14:28 Growth hormone mutants and lifespan
15:42 FOXO3a and longevity in humans
17:10 APOE genes and longevity in humans
18:06 Things to keep in mind when talking about aging genes
22:35 Matt blows your mind
31:03 Wrapping up

Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.

More places to find us:

Twitter:   / optispanpodcast  
Twitter:   / optispan  
Twitter:   / mkaeberlein  
Linkedin:   / optispan  

https://www.optispan.life/

Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!