How Ketones Take out the Trash: New Research on Diet and Brain Aging

New data reveal how ketone bodies, produced on a ketogenic diet, help manage pathological protein misfolding that characterizes Alzheimer’s disease and other neurodegenerative diseases like Parkinson’s disease. Quoting from the paper, “ketone bodies are janitors of damaged proteins, chaperoning away molecular waste so organisms can operate at peak molecular fitness.” We simplify and demystify the data so you can understand its importance. And, if you stick around, we include an exclusive clip from the research team.

Chapters
0:00 – New Paper on Alzheimer’s Disease
0:44 – Background on Protein Misfolding
1:46 – Background on Keto and Alzheimer’s
2:58 – New Paper’s Main Findings
4:50 – An Analogy
5:08 – Key Data from the Paper
6:08 – How Do Ketones Know How to Target Misfolded Proteins?
7:57 – New Frontier of Biology
8:50 – Words from the Researcher

References:

Madhaven S.S. et al. Beta-hydroxybutyrate is a metabolic regulator of
proteostasis in the aged and Alzheimer disease brain. Cell Chemical Biology. 2024

Phillips M.C. et al. Randomized crossover trial of a modified ketogenic diet in Alzheimer's disease. Alzheimer’s Research and Therapy. 2021

Norwitz N.G. et al. Ketotherapeutics for Neurodegenerative Diseases. International Review of Neurobiology (textbook). 2020

#brainhealth #ketones #alzheimersdisease #ketodiet #metabolism #metabolichealth #staycurious