The Hallmarks of Aging: Altered Intercellular Communication | LifeXtenShow

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Cells in your body don’t exist as isolated units; they talk to each other, and correct intercellular communication is essential for your health. Unfortunately, intercellular communication goes south as you get older, and that’s one of the reasons we wind up getting a bunch of nasty diseases later in life. Can we fix that? Possibly!

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Music:

Intro jingle courtesy of Kevin MacLeod - Incompetech.com

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Sources:

The Hallmarks of Aging
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217.
(https://www.ncbi.nlm.nih.gov/pmc/arti...)

Parabiosis
Loffredo, F. S., Steinhauser, M. L., Jay, S. M., Gannon, J., Pancoast, J. R., Yalamanchi, P., ... & Miller, C. M. (2013). Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell, 153(4), 828-839. (https://www.ncbi.nlm.nih.gov/pubmed/2...)

Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., ... & Lucin, K. M. (2011). The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature, 477(7362), 90.
(https://www.ncbi.nlm.nih.gov/pubmed/2...)

Rebo, J., Mehdipour, M., Gathwala, R., Causey, K., Liu, Y., Conboy, M. J., & Conboy, I. M. (2016). A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. Nature communications, 7, 13363.
(https://www.ncbi.nlm.nih.gov/pubmed/2...)

Dr. Irina Conboy: Could Filtering Our Aged Blood Keep us Young? (https://www.leafscience.org/conboy-in...)

Alkahest clinical trials
Clinicaltrials.gov (https://clinicaltrials.gov/ct2/result...)

Alkahest
https://www.lifespan.io/alkahest-chro...

Rejuvenation Roadmap
https://www.lifespan.io/roadmap
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#Inflammation #Aging #Inflammaging #Parabiosis #MolecularBiology #Biology #LifeExtension

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