Regulation of Microtubule Dynamics During Growth Cone Guidance and Cell Migration

Presented By: Laura Anne Lowery, PhD

Speaker Biography: Dr. Laura Lowery is a cell biologist and Associate Professor at Boston University School of Medicine. Dr. Lowery received her PhD in Biology from the Massachusetts Institute of Technology and completed her postdoctoral studies at Harvard Medical School. At the Boston Medical Center, the Lowery laboratory investigates the mechanisms that drive cell motility in both normal and pathological conditions, focusing on the cell biological defects that underlie complex neurodevelopmental disorders as well as cancer metastasis.

Webinar: Regulation of Microtubule Dynamics During Growth Cone Guidance and Cell Migration

Webinar Abstract: Microtubule plus-end tracking proteins (+TIPs) play key roles in the regulation of microtubule dynamics in vivo. These proteins bind to and regulate microtubule “plus‐ends”, which are the dynamic ends that explore and interact with the cellular periphery. Despite their importance, it is still unclear how various +TIPs interact with each other and with plus‐ends to control microtubule behaviors, particularly in vivo. My lab studies +TIP function by quantitative analysis of microtubule plus-end behaviors using high‐resolution live‐imaging data of cultured embryonic Xenopus laevis cells. Previously, we demonstrated that the transforming acidic coiled‐coil (TACC) domain family member, TACC3, can function as a +TIP to promote microtubule polymerization dynamics, in collaboration with the microtubule polymerase, XMAP215. In this talk, I will discuss recent work on how TACC3 may be mediating axon guidance, as well as how its binding partner, XMAP215, appears to promote MT-F-actin interaction in embryonic neuronal growth cones.

Earn PACE Credits:
1. Make sure you’re a registered member of LabRoots https://www.labroots.com/virtual-even...
2. Watch the webinar on YouTube or on the LabRoots Website https://www.labroots.com/webinar/regu...
3. Click Here to get your PACE credits (Expiration date – September 22, 2023): https://www.labroots.com/credit/pace-...

LabRoots on Social:
Facebook:   / labrootsinc  
Twitter:   / labroots  
LinkedIn:   / labroots  
Instagram:   / labrootsinc  
Pinterest:   / labroots  
SnapChat: labroots_inc