6.07. Tetracyclines (doxycycline): A Clinical Overview

Doxycycline is one of the most versatile and widely used antibiotics in the world. But do you know all the critical details for prescribing it safely and effectively?

This comprehensive clinical overview provides a deep dive into the tetracycline antibiotic class, with a special focus on the workhorse drug, Doxycycline. We cover everything from the core mechanism of action at the 30S ribosome to its key clinical applications in treating Chlamydia and Lyme disease. Learn the precise dosing strategies and the critical drug interactions you must watch for, such as chelation with antacids. We'll also explore the most important side effects, like photosensitivity, and discuss the absolute contraindications that every clinician must know: use in pregnancy and young children. Finally, we'll touch on the current landscape of resistance and why stewardship is essential for this cornerstone antibiotic.

🕒 Timestamps:

00:00 - Introduction to Tetracyclines
01:01 - 1. Core Principles & Patient Counseling
01:56 - 2. Key Clinical Applications (Chlamydia & Lyme Disease)
02:46 - 3. Dosage & Critical Interactions
03:58 - 4. Side Effects (Photosensitivity & More)
04:56 - 5. Absolute Contraindications (Pregnancy & Children)
05:51 - 6. The Challenge of Resistance

Sources:
This video was made with Gemini's deep research capabilities and NotebookLM.

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