Remarkable Rapid Revision 2.0 — Biochemistry 🚀 Dr Smily Pruthi | High-Yield Marathon FMGE Jan 2026 🧬

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Remarkable Rapid Revision 2.0 — Biochemistry 🚀 Dr Smily Pruthi | High-Yield Marathon FMGE Jan 2026 🧬🧪

Ace Biochem with image-led maps, PYQ wiring, and zero fluff. Metabolism big picture fed versus fasting hormones insulin and glucagon with AMPK switches; carbs glycolysis key regulators PFK1, pyruvate kinase, pyruvate dehydrogenase thiamine dependent, TCA checkpoints isocitrate and alpha-KG dehydrogenase, ETC inhibitors rotenone antimycin cyanide, oxidative phosphorylation and uncouplers; glycogen synthesis and breakdown enzyme pairs glycogen synthase and phosphorylase, Pompe McArdle Cori; gluconeogenesis irreversible steps pyruvate carboxylase biotin, PEPCK, F1,6BPase, G6Pase; HMP shunt G6PD and NADPH uses favism, WBC oxidative burst; fructose and galactose disorders aldolase B and galactose-1-P uridyltransferase cataracts in infants. Lipids beta oxidation CPT1 carnitine shuttle, MCAD deficiency hypoketotic hypoglycaemia, ketone bodies in prolonged fasting, de novo fatty acid synthesis ACC and FAS, cholesterol HMG-CoA reductase statins, lipoproteins familial hyperlipoproteinaemias Type IIa LDL receptor and Type I LPL deficiency; essential fatty acids and eicosanoids. Proteins and nitrogen urea cycle CPS1 and OTC with hyperammonaemia therapies benzoate phenylbutyrate, transamination ALT AST B6, aromatic amino acid disorders PKU phenylalanine hydroxylase, MSUD branched-chain dehydrogenase, alkaptonuria homogentisate oxidase; one-carbon metabolism folate and B12 megaloblastosis and methylmalonic acidemia. Acid–base and ABG quick reads anion gap metabolic acidosis and respiratory compensation Winter’s formula; electrolytes sodium, potassium, calcium–phosphate PTH vitamin D and calcitonin axis. Vitamins and minerals fat-soluble A D E K classic deficiencies VKDB in newborns, water-soluble B1 beriberi and Wernicke, B2 cheilosis, B3 pellagra 3 Ds, B6 neuropathy and sideroblastic, B12 with neurologic signs, C scurvy; iron hepcidin logic, TIBC ferritin patterns IDA versus ACD. Molecular biology replication DNA pol inhibitors, transcription and splicing, translation with initiation factors, post-translational mods, enzyme kinetics Km Vmax competitive versus non-competitive, PCR cycles, blotting types southern DNA, northern RNA, western protein, ELISA and CLIA, microarrays and next-gen basics. Hormones peptide versus steroid receptors, second messengers cAMP cGMP IP3 DAG tyrosine kinase JAK-STAT; thyroid, cortisol, GH and insulin signalling pearls. Clinical biochemistry cardiac markers troponin, CK-MB; liver panel AST ALT ALP GGT and patterns, bilirubin metabolism unconjugated versus conjugated, prehepatic hepatic posthepatic jaundice; renal markers creatinine urea eGFR and RTA types; diabetes diagnosis HbA1c fasting and 2 hour cut-offs, DKA versus HHS labs. Nutrition and inborn errors newborn screening panels, RDA basics, Kwashiorkor versus Marasmus, refeeding syndrome. Close with drug of choice style tables for cofactor-enzyme pairs, spotters for pathway defects, and rapid one-liners to solve each vignette in under 30 seconds—mark and move.

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