Why Your Skin Changes at 40+ (Perimenopause, Estrogen Loss & How to Rebuild Collagen)

f your skin suddenly feels thinner, drier, more reactive, or “older” in your 40s — you’re not imagining it.

This is one of the earliest and most visible signs of perimenopause. Estrogen fluctuations dramatically impact collagen production, skin thickness, barrier repair, and inflammation — which is why so many women notice rapid changes in their skin long before menopause officially begins.

In this video, I break down why skin aging accelerates after 40, what’s happening at the hormonal and cellular level, and the evidence-based strategies I personally use to support collagen, firmness, and overall skin health during the menopause transition.

We cover:
• The role of estrogen in collagen, elastin, hydration, and skin thickness
• Why collagen loss accelerates in perimenopause
• How tretinoin, vitamin C, and peptides influence gene expression
• Why GHK-Cu is one of my favorite skin peptides for women 40+
• My personal routine: microneedling, chemical peels, and collagen biostimulators
• How Radiesse and Sculptra stimulate your own collagen production
• Why gut health and the microbiome matter so much for skin aging in midlife

This is the same science-based approach I use in my 1:1 coaching and private women’s peptide community.

🔗 LINKS & RESOURCES MENTIONED

GHK-Cu Serum
👉 [INSERT LINK]

GHK-Cu Peptide (injectable – educational discussion only)
👉 [INSERT LINK]

Alloy M4 Estrogen Face Serum (prescription)
👉 [INSERT LINK]

Vitamin C Serums I Use & Recommend
• Medik8 C-Ferulic
👉 [INSERT LINK]
• Jan Marini C-ESTA
👉 [INSERT LINK]

Tretinoin (prescription)
👉 [INSERT LINK or prescribing workflow]

Platinum Skincare Chemical Peels
👉 [INSERT LINK]
(Optional code: DRKRISTI)

Microneedling (device or in-clinic provider)
👉 [INSERT LINK]

Radiesse / Sculptra (collagen biostimulators – educational)
👉 [INSERT LINK]

Gut-Support Peptides (KPV, BPC-157)
👉 [INSERT LINK]

Omega-3s & Supplements Mentioned
👉 [INSERT LINK (Amazon storefront or affiliate page)]

Resources Mentioned:
• Women’s Wellness Community (WOW): https://women-s-optimized-wellness.mn...
• 1:1 Peptide & Optimization Consults: https://www.kristisawicki.com/1-1-coa...
• Peptide Guide (Research-Use-Only / educational): https://drkristi.myflodesk.com/ftgvlz...
• Full Metabolic + Hormone Lab Panel Function Health: https://women-s-optimized-wellness.mn...

If you enjoyed this episode, hit subscribe — we’re just getting started and I’m bringing you the smartest, science-backed tools for midlife health optimization.


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