The INSANE Exploits Tuberculosis Uses to Break You

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🦠 Mycobacterium Tuberculosis is the single-deadliest pathogen across all of human history. How can this ancient disease be so persistent even in the face of modern medicine? One key place to start is seeing how Tuberculosis hacks into and defeats our immune system at the molecular level. Your immune system is incredibly fine-tuned, and yet somehow TB has an answer to every single one of your immune attacks. Let's explore the diabolical ways TB undermines our most basic defenses and how that's allowed Tuberculosis to stick with us for (potentially) hundreds of thousands of years.

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📚Primary Works Cited:

Chandra, P., Grigsby, S.J. & Philips, J.A. Immune evasion and provocation by Mycobacterium tuberculosis. Nat Rev Microbiol 20, 750–766 (2022). https://doi.org/10.1038/s41579-022-00...

Dulberger CL, Rubin EJ, Boutte CC. The mycobacterial cell envelope - a moving target. Nat Rev Microbiol. 2020;18(1):47-59. doi:10.1038/s41579-019-0273-7