How a 25-Person Team Built a $3.5B Company | OpenEvidence Co-founder & CTO Zack Ziegler

On the heels of raising $210 million at a $3.5 billion valuation, OpenEvidence is the fastest-growing physician app in history, now reaching over 40% of U.S. physicians and powering 17 million monthly clinical queries.

In this conversation, co-founder and CTO Zack Ziegler shares how his background in early large language models led him to build an AI that helps clinicians make better decisions at the point of care, without replacing their judgment.

We cover:
🧠 The strategies Open Evidence used to reach 40% of U.S. clinicians in a short time
💡 The unexpected reason they chose to go direct to doctors instead of via their employers
💰 How they make money
⚙️ What “Deep Consult” means for the future of clinical decision-making
🏥 Whether tools like this could ever—or should ever—be available to patients

About our guest:
Zachary Ziegler is the cofounder and CTO of OpenEvidence, the leading medical information platform. Designed from the ground up for medical professionals, OpenEvidence organizes and expands the world's medical knowledge to make it more useful, open, accessible, and understandable. Launched out of the Mayo Clinic Platform Accelerate, OpenEvidence has become the most rapidly adopted tool by physicians in history, now used by over 40% of US physicians in over 15,000 care centers across the United States. Before founding OpenEvidence, Ziegler was a PhD student at Harvard University, where he worked with Professor Sasha Rush and was awarded the National Science Foundation Graduate Research Fellowship. He completed his undergraduate studies at Cornell University, where he received the Barry Goldwater Scholarship.