[Conférence] A. VARSHAVSKY - Lecture
Автор: Académie des sciences
Загружено: 2016-12-22
Просмотров: 1595
00:00:00 Introduction
00:02:37 Regulated degradation
00:03:54 The ubiquitin system
00:10:23 The ubiquitin fusion technique
00:12:48 The Ub fusion technique and the N-end rule pathway
00:14:54 The mammalian Arg/N-end rule pathway
00:21:36 The N-end rule pathway in the yeast S. cerevisiae
00:28:43 The mechanics of N-degron
00:35:10 Caspase-generated proapoptotic fragments of specific cellular proteins as short-lived substrates of the Arg/N-end rule pathway [set #1]
00:36:53 Impaired neurogenesis and cardiovascular development in UBR1[-/-]UBR2[-/-] double mutants
00:40:14 Steric shielding of Nt-acetylated N-terminal residue
00:41:32 Some Former Lab Members and Current Lab Members
00:42:55 Questions and Answers
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