Fluoroquinolones | 2nd vs 3rd vs 4th Generation | Targets, Mechanism of Action

Lesson on the Fluoroquinolone (Quinolone) antibiotics ciprofloxacin vs. levofloxacin vs. moxifloxacin. Fluoroquinolones include the antibiotics with the suffix -floxacin. Earlier generations of quinolones have activity against gram negative bacteria, whereas later generations have additional activity against gram positive bacteria and anaerobes. The mechanism of action is similar amongst all fluoroquinolones, whereby they target 2 specific bacterial enzymes involved in bacterial DNA synthesis, causing DNA damage and bacterial cell death. Fluoroquinolone use can cause a variety of adverse reactions, with some of these reactions preventing their use in children and pregnant women.

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JJ

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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JJ