Anti-SSA (Anti-Ro) Autoantibodies - Sjögren Syndrome - Rheumatology and Immunology

Autoantibodies are antibodies against the self.
Anti_SSA (anit_Ro) antibodies are seen in sjögren syndrome (SS) as well as systemic lupus erythematosus (SLE).
Anti-SSA (anti_Ro) autoantibodies are associated with non-Hodgkin's lymphoma in patients with Sjögren syndrome.

Anti-double stranded DNA antibodies (anti-dsDNA) are autoantibodies against extracellular double-stranded DNA...They are associated with systemic lupus erythematosus (SLE)...They are very specific for lupus, yet, they are not very sensitive for SLE.
Anti-cyclic citrullinated peptide (anti-CCP) are autoantibodies that are present in the serum of most patients of rheumatoid arthritis...These anti-CCP antibodies are not sensitive, but they are very specific.
Citrullination is a method of post-translational modification (PTM) in molecular biology...Modifying arginine into citrulline via deimination (not to be confused with deamination).


Rheumatoid factor (RF) is an IgM autoantibody against the Fc portion of IgG. "an antibody against an antibody".
Rheumatoid factor (RF) is present in 80% of patients with rheumatoid arthritis (RA), which makes this test 80% sensitive.
Rheumatoid factor (RF) is not specific, because it can be seropositive in many diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), sjögren syndrome, interstitial pulmonary fibrosis, hepatitis B infection, essential mixed cryoglobulinemia, infective endocarditis (subacute bacterial endocarditis or SABE), tuberculosis, infectious mononucleosis (mono) and hematological malignancies...This, by definition, is non-specific.

Anti-neutrophilic cytoplasmic antibodies (ANCA) are IgG autoantibodies against the cytoplasm of the neutrophils and monocytes.
This is different from antinuclear antibodies (ANA) which are antibodies against the nucleus.
Anti-neutrophilic cytoplasmic antibodies (ANCA) have several patterns; the most important two being the cytoplasmic ANCA (c-ANCA) and the perinuclear ANCA (p-ANCA).
Anti-neutrophilic cytoplasmic antibodies (ANCA) are associated with vasculitis, such as granulomatosis with polyangiitis (Wegener granulomatosis), microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss), rapidly-progressive glomerulonephritis (RPGN), anti-glomerular basement membrane antibodies (ant-GBM or Goodpasture's syndrome), as well as inflammatory bowel disease-associated. vasculitis.

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In brief, anti-SSA autoantibodies (anti-Ro) are seen in Sjögren and SLE. If you like my videos, please consider leaving a tip at https://www.paypal.me/perfectionalis/
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