Fallout 4: Relay Tower 0BB 915, Fort Hagen Filling Station, and Fort Hagen

Fallout 4 takes place in the year 2287, 10 years after the events of Fallout 3 and 210 years after the Great War, a war between the United States and China over natural resources that ended in a nuclear holocaust in 2077. The setting is post-apocalyptic, covering a region that includes Boston and other parts of New England known as "The Commonwealth". Unlike the previous titles, Fallout 4's story begins on the day the bombs dropped: October 23, 2077.

In the Commonwealth during the year 2077, the protagonist and their family—consisting of their husband Nate or wife Nora, depending on the player's chosen sex, and their baby son Shaun—escape into Vault 111, gaining entry due to a Vault-Tec representative signing them up for it immediately prior to a nuclear attack. Inside, the family members are tricked into entering cryogenic pods and frozen alive. 150 years later, the protagonist's spouse is killed and Shaun is taken away by a mysterious group. The life support system malfunctions at a later date and unfreezes the protagonist, who leaves their pod to find the remaining residents of Vault 111 deceased, gaining the nickname of the "Sole Survivor".