NEW 2025 Meta-Analysis: RCTs Don’t Support Restricting Saturated Fat

For decades, we've been told that saturated fat is harmful to heart health. But is it finally time to stop blaming butter and other sources of saturated fat for heart disease? In this video, we dive into a new 2025 meta-analysis of randomized controlled trials (RCTs) that reveals “the evidence available from RCTs does not support saturated fat restriction for the prevention of cardiovascular disease.”

The study challenges long-standing beliefs about dietary fat and its role in heart health, sparking a crucial conversation about how we approach heart disease prevention and cholesterol management. We’ll explore the implications of this new evidence, discuss why there's still confusion around this issue, and offer practical insights on healthy fats, dietary guidelines, and cardiovascular health.

Stay tuned for key takeaways from this meta-analysis and learn why saturated fat might not be the culprit we've been led to believe.

REFERENCES AND MORE INFORMATION
A written breakdown of these data will all references hyperlinked can be found in the June 16, 2025, letter at: http://StayCuriousMetabolism.com . The letter includes descriptions on how to understand forest plots, my conflicts of interest, which are certainly not aligned with “Big Butter” – quite the opposite, actually.

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Stearic Acid & Mitochondrial Health: https://staycuriousmetabolism.substac...
Sat Fat N = 1:    • I Ate 2000 Calories of Saturated Fat a Day...  

Chapters
0:00 – A New 2025 Meta-Analysis of Randomized Controlled Trials: Is It the Saturated Fat?
0:49 – Why There’s Still Confusion Around Saturated Fat and Heart Disease
1:13 – The Meta of RCTs Says: No Benefits to Reducing Saturated Fat Intake
2:50 – No Dose-Response: Less Butter Isn’t Better
3:43 – Summary: “The existing Human RCT data do not support…”
4:00 – Discrepancies Among Meta-Analyses: What Should We Trust?
5:25 – Why the Status Quo Persists in Saturated Fat Guidelines
6:32 – Financial Influences in Dietary Recommendations
7:13 – Saturated Fat: Oversimplified and Misunderstood
10:38 – Individual Differences: Why We Respond Differently to Saturated Fat
11:53 – How to Measure Cholesterol Levels at Home
12:18 – Revising the Evidence: Let’s Focus on Data, Not Dogma

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