Precision cardiovascular medicine | Frontiers in Science

Despite medical progress, cardiovascular diseases remain the world’s leading cause of death. Their complexity and heterogeneity mean that one-size-fits-all treatments leave many patients at risk. Could an integrative precision approach deliver more effective, tailored care?

Aikawa et al. describe a paradigm combining systems biology, network medicine, and AI-powered big data analysis to unravel disease mechanisms, identify new biomarkers and therapeutic targets, and develop novel therapies. Their lead article examines advances in omics, computational drug design, and RNA therapeutics—highlighting the policies and collaborations needed to implement this paradigm globally.

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Citation:
Aikawa M, Sonawane AR, Chelvanambi S, Asano T, Halu A, Matamalas JT, Singh SA, Uchida S, Aikawa E, Arenas A, Balligand J-L, Giannarelli C, MacRae CA, Morgan NV, Oury C, Tevaearai Stahel H and Loscalzo J. Precision cardiovascular medicine: shifting the innovation paradigm. Front Sci (2025) 3:1474469. doi: 10.3389/fsci.2025.1474469