Perimenopause Expert Doctor Tells the TRUTH About Hormones, Muscle Loss & Women’s Longevity SECRETS

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Women today are living longer than ever — but often spend the final decades of life in poor metabolic, hormonal, and cardiovascular health. In this powerful episode, OB/GYN and women’s health expert Dr. Jessica Shepherd breaks down everything women need to know about perimenopause, menopause, hormones, strength training, and longevity after 40.

We dive into the 82% drop in hormone therapy prescriptions after 2002, the staggering truth that only 8% of women get diagnosed despite having perimenopause symptoms, and why muscle is the organ of longevity — especially as women lose 3–5% of muscle mass per decade.

Dr. Shepherd explains how declining estrogen affects brain health, mood, inflammation, cardiovascular risk, metabolism, mitochondrial function, hot flashes, sleep, weight gain, and more. We also explore the role of resistance training, protein, supplements like creatine and CoQ10, and the growing science around ovarian longevity.

If you’re a woman entering midlife — or you love a woman who is — this is the most important conversation you will hear about navigating perimenopause, hormone therapy, and the path to aging strong.

📌 Topics Covered:
• Early signs of perimenopause
• Hormone therapy myths & the WHI study
• Why women lose muscle mass & how to rebuild it
• Estrogen’s role in heart, brain & metabolic health
• How women can advocate for better care
• Nutritional & exercise strategies for women 40+
• Longevity science & aging well

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00:00 – Women’s health crisis: why longevity isn’t enough

00:28 – Muscle as the organ of longevity

01:18 – Estrogen decline & whole-body impact

02:15 – Why women don’t think about longevity early enough

04:23 – Mindset, habits & community

07:13 – Barriers to wellness for women

09:33 – The real state of women’s health

12:46 – Research gaps & lack of funding (only 3% of VC goes to women’s health)

17:30 – How pharma abandoned women’s health

19:10 – What perimenopause actually is

24:45 – Estrogen & heart disease risk

27:02 – Mood, stress & hormone shifts

29:48 – Hormone therapy: what we now know

32:32 – Why only 5% of women are on HRT

34:20 – WHI study misinterpretation & fear

39:06 – Risk vs. benefit clarity

41:51 – Chase’s TRT story & hormone literacy

45:16 – Dr. Shepherd’s hormone journey

48:12 – Supplements for women over 40

50:10 – Muscle, mitochondrial health & metabolism

52:25 – Movement, neuroplasticity & aging well

55:12 – How partners can better support women

59:22 – What menopause really means

01:02:39 – Nutrition & metabolic health

01:07:07 – Protein, strength training & women over 40

01:09:37 – The diagnosis gap (only 8% diagnosed)

01:12:34 – Which providers to see for menopause

01:15:31 – Comorbidities rise 45% between ages 40–59

01:18:25 – Can we biohack menopause?

01:22:24 – Exercise as the ultimate biohack

01:23:19 – How Dr. Shepherd lives Ever Forward

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women’s health
perimenopause
menopause
perimenopause symptoms
menopause symptoms
hormone therapy
hrt safety
estrogen decline
women over 40
women over 50
longevity for women
muscle loss women
muscle loss menopause
sarcopenia women
metabolism after 40
women strength training
women protein intake
midlife health
women’s hormones
female hormone balance
hot flashes
night sweats
brain fog women
menopause weight gain
menopause belly fat
estradiol
progesterone
testosterone women
bioidentical hormone therapy
WHI study
women’s heart disease
women’s brain health
aging women
anti-aging women
longevity science
mitochondrial health
creatine for women
CoQ10 women
urolithin A
P-Volv
pelvic health
women’s fitness
women’s metabolic health
Chase Chewning
Ever Forward Radio
Dr Jessica Shepherd