*LIVE Session* (preview) | Hypopituitarism | ABIM & USMLE
Автор: IM MEDICAL
Загружено: 2025-03-11
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🔴 Hypopituitarism Explained Perfectly | ABIM & USMLE High-Yield Review
In this high-yield medical lecture, we dive deep into Hypopituitarism, a condition characterized by partial or complete deficiency of anterior and/or posterior pituitary hormones. This is a highly tested topic on ABIM & USMLE exams, and mastering it is crucial for both exam success and clinical practice.
🔬 Key Topics Covered:
✅ Pathophysiology of Hypopituitarism – Understanding primary vs. secondary causes
✅ Common Causes:
🔹 Pituitary Tumors – Compression & destruction of pituitary cells
🔹 Sheehan’s Syndrome – Postpartum pituitary infarction
🔹 Pituitary Apoplexy – Sudden hemorrhage in a pituitary adenoma
🔹 Radiation, Trauma, and Infiltrative Diseases – Sarcoidosis, hemochromatosis
✅ Hormone Deficiencies & Clinical Manifestations:
🔹 ACTH Deficiency → Secondary Adrenal Insufficiency (Fatigue, hypotension, hypoglycemia)
🔹 TSH Deficiency → Secondary Hypothyroidism (Cold intolerance, weight gain, bradycardia)
🔹 LH/FSH Deficiency → Hypogonadism (Amenorrhea, infertility, decreased libido)
🔹 GH Deficiency → Growth failure in children, reduced muscle mass in adults
🔹 Prolactin Deficiency → Inability to lactate postpartum
✅ Diagnosis & Lab Findings:
🔹 Morning Cortisol & ACTH Levels – Differentiating primary vs. secondary adrenal insufficiency
🔹 TSH & Free T4 Levels – Recognizing secondary hypothyroidism
🔹 LH/FSH & Testosterone/Estradiol Levels – Assessing gonadal function
🔹 Insulin Tolerance Test (Gold Standard) for GH & ACTH Deficiency
🔹 MRI Pituitary – To evaluate for tumors, infarction, or infiltrative disease
✅ Management Strategies:
🔹 Hormone Replacement Therapy (HRT) Based on Deficiency:
Hydrocortisone or prednisone for ACTH deficiency
Levothyroxine for TSH deficiency
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