Dendritic Cells - Functions

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Discover the different types of dendritic cells, their unique characteristics, and their role in presenting antigens, all comprehensively discussed in this video. Are you ready for a glimpse of the fascinating insights this immunology video has in store for you?

▬ Dendritic Cells ▬▬▬▬▬▬▬▬▬▬
Dendritic cells are the Bone marrow-derived cells that are found in almost all tissues of the body. But they are mostly found in tissues, that have direct contact with the outside environment such as Epithelial cells of the skin, or Mucosal lining of the nose, lungs, and GIT.

Here, in this section, you will learn, how different types of dendritic cells play their role mainly as “Antigen Presenting Cells”.

▬ Antigen Processing and Presentation ▬▬▬▬▬▬▬▬▬▬
Macrophages and B cells also play a role as Antigen-presenting cells. But Dendritic cells are considered the “Efficient APCs”, as they perform this role much more efficiently.

Dendritic cells have undergone some adaptations to be such good Antigen presenters, and these adaptations are:
🟠 Extensive dendritic processes
🟠 Motility from bone marrow to peripheral tissues
🟠 Upregulation of receptors such as TLRs
🟠 Cytokines secretion

▬ Types of Dendritic Cells ▬▬▬▬▬▬▬▬▬▬
Dendritic cells are usually classified as:
🟡 Myeloid dendritic cells (mDCs)
🟡 Plasmacytoid dendritic cells (pDCs)

Dendritic cells are formed by the Hematopoietic stem cells. And inside the tissues, they remain in their Inactive form. But once they encounter the pathogen or any foreign particle, they get activated, and under the influence of certain cytokines, they migrate from tissues to the Lymphatic organs, mainly Lymph nodes where CD4 T cells are in abundance.

Also, antigen directly enters the spleen and other lymphoid organs, where they are taken up by dendritic cells:
🔵 Pinocytosis
🔵 Receptor-mediated endocytosis
🔵 Phagocytosis

How these mechanisms work, and how dendritic cells take up antigens and present them to T-cells are all explained in this video. So, for a detailed understanding Watch this video at sqadia.com.