Adenosine Masterclass: Your Best Guide to SVT, AV Node Physiology, and Life-Saving Decisions

Unlock the deepest, most advanced explanation of adenosine ever made for critical-care clinicians. This masterclass breaks down the real electrophysiology behind A1 receptors, Kir3 channels, Gi proteins, AV-node microstructure, stopcock delivery physics, and the high-stakes decisions that separate the top 0.1 percent from everyone else.
Time Stamp Title/Topic
[00:00:00] Introduction: Therapeutic & Diagnostic Instrument
[00:00:29] AV Node Anatomy: A 1Receptor Physiology
[00:00:56] Mechanism of Action: GiProtein & I KAch Current
[00:01:18] Metabolism, Clearance, and Drug Interactions
[00:01:43] Therapeutic Use: AV-Node Dependent Tachycardias (AVNRT, AVRT)
[00:02:05] Diagnostic Use: SVT with Aberrancy vs. VT Differentiation
[00:02:48] Key Contraindications (Pre-excited AF, Transplant Hypersensitivity)
[00:03:11] Adult Dosing Sequence and Special Populations
[00:03:30] The Essential Stopcock Method
[00:04:15] Physics of Flow: Optimizing Drug Delivery
[00:04:33] Efficacy Summary: Rapid Action & Safety Profile
[00:04:54] Interpreting Non-Response (Failure Analysis)
[00:05:13] Differentiating Non-AV-Node Dependent Rhythms
[00:05:33] Common Side Effects and Adverse Events
[00:06:00] Advanced Clinical Mastery
[00:06:14] Final Conclusion: Expert Integration
Learn how adenosine works, why milliseconds matter, how to perform the stopcock method correctly, how to differentiate SVT with aberrancy from VT, and how to avoid lethal pitfalls like pre-excited AF. This is the definitive resource for ICU nurses, CTICU teams, electrophysiologists, emergency physicians, CRNAs, and cardiology fellows.
Covered in this video
• Exact mechanism of action down to channels and G-proteins
• AV nodal microarchitecture and A–H interval physiology
• Proper stopcock delivery technique and why speed determines success
• Indications, contraindications, high-risk scenarios
• EP-level interpretation of adenosine failure
• How to recognize JT vs AT vs VT
• Transplant physiology microdosing
• Wide-complex tachycardia diagnostic strategy
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