Breast Cancer Treatment: How CDK4/6 Inhibitors Work (monarchE & NATALEE Trials)
Автор: OncologyTube
Загружено: 2025-07-18
Просмотров: 620
Article: https://oncologytube.com/breast-cance...
Learn how CDK4/6 inhibitors like abemaciclib and ribociclib improve breast cancer treatment for HR+/HER2- early-stage patients by addressing hormone therapy resistance. Dr. Austin Williams from Fox Chase Cancer Center discusses their mechanism, results from the monarchE and NATALEE trials, and future applications for patients and clinicians.
Timestamps:
0:00 - Introduction to CDK4/6 Inhibitors
0:06 - How CDK4/6 Inhibitors Address Hormone Therapy Resistance
0:40 - monarchE Trial: Abemaciclib Results
1:05 - NATALEE Trial: Ribociclib Results
1:29 - Comparing monarchE and NATALEE Trials
2:40 - Why Palbociclib Failed in Early Breast Cancer
3:50 - Future Applications of CDK4/6 Inhibitors
4:37 - Guidance for Surgeons
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