Other genetic Mutation susceptibilities to breast cancer

In addition to the well-known BRCA1 and BRCA2 mutations, several other genetic mutations are associated with an increased risk of breast cancer. Here are some examples:

PALB2: Works alongside BRCA2 to repair DNA damage. Mutations in PALB2 significantly increase breast cancer risk.

CHEK2: Produces a protein that suppresses tumor growth. Mutations in CHEK2 double the risk of breast cancer in women and increase the risk of male breast cancer.

ATM: Involved in DNA repair. Mutations in ATM are linked to a higher risk of breast cancer.

CDH1: Associated with lobular breast cancer and hereditary diffuse gastric cancer.

PTEN: Linked to Cowden syndrome, which increases the risk of breast and other cancers.

TP53: Known as the "guardian of the genome," mutations in TP53 are associated with Li-Fraumeni syndrome and a higher risk of breast cancer.

RAD51C and RAD51D: Involved in DNA repair, with mutations linked to breast and ovarian cancer

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