#69: La fatiga en la esclerosis múltiple | Hemispherics

En el episodio de hoy, indagamos en la fisiopatología de la fatiga para entender mejor este fenómeno, también diferentes formas de ver la fatiga con sus distintas nomenclaturas o términos, vamos a ver cómo se suele evaluar en el entorno clínico y en investigación y finalmente daremos algunas pinceladas de tratamiento neuromodulador.

Referencias del episodio:

1. Adibi, I., et al. (2022). Multiple sclerosis-related fatigue lacks a unified definition: A narrative review. (https://pubmed.ncbi.nlm.nih.gov/35419....

2. Ayache, S. S., & Chalah, M. A. (2017). Fatigue in multiple sclerosis - Insights into evaluation and management.(https://pubmed.ncbi.nlm.nih.gov/28416....

3. Ayache, S. S., et al (2022). Fatigue in Multiple Sclerosis: A Review of the Exploratory and Therapeutic Potential of Non-Invasive Brain Stimulation. (https://pubmed.ncbi.nlm.nih.gov/35572....

4. Braley, T. J., & Chervin, R. D. (2010). Fatigue in multiple sclerosis: mechanisms, evaluation, and treatment. (https://www.ncbi.nlm.nih.gov/pmc/arti....

5. Capone, F., et al (2020). The Potential Role of Neurophysiology in the Management of Multiple Sclerosis-Related Fatigue. (https://www.ncbi.nlm.nih.gov/pmc/arti....

6. Chalah, M. A., et al (2015). Fatigue in Multiple Sclerosis: Neural Correlates and the Role of Non-Invasive Brain Stimulation. (https://pubmed.ncbi.nlm.nih.gov/26648....

7. Chalah, M. A., et al (2019). Neurophysiological, radiological and neuropsychological evaluation of fatigue in multiple sclerosis. (https://pubmed.ncbi.nlm.nih.gov/30594....

8. Dittner, A. J. et al (2004). The assessment of fatigue: a practical guide for clinicians and researchers. (https://pubmed.ncbi.nlm.nih.gov/15016....

9. Dobryakova, E., et al (2015). The dopamine imbalance hypothesis of fatigue in multiple sclerosis and other neurological disorders. (https://pubmed.ncbi.nlm.nih.gov/25814....

10. Gaede, G., et al (2017). Safety and preliminary efficacy of deep transcranial magnetic stimulation in MS-related fatigue. (https://pubmed.ncbi.nlm.nih.gov/29259....

11. Garis, G., et al (2023). Heart rate variability and fatigue in MS: two parallel pathways representing disseminated inflammatory processes?. (https://pubmed.ncbi.nlm.nih.gov/36125....

12. Hanken, K et al (2014). The representation of inflammatory signals in the brain - a model for subjective fatigue in multiple sclerosis. (https://pubmed.ncbi.nlm.nih.gov/25566....

13. Iriarte, J. et al (2000). Modalities of fatigue in multiple sclerosis: correlation with clinical and biological factors. (https://pubmed.ncbi.nlm.nih.gov/10773....

14. Jaeger, S., et al. (2019). Multiple sclerosis-related fatigue: Altered resting-state functional connectivity of the ventral striatum and dorsolateral prefrontal cortex. (https://pubmed.ncbi.nlm.nih.gov/29464....

15. Linnhoff, S., et al (2019). Cognitive Fatigue in Multiple Sclerosis: An Objective Approach to Diagnosis and Treatment by Transcranial Electrical Stimulation. (https://pubmed.ncbi.nlm.nih.gov/31052....

16. Liu, M. et al (2019). Non-invasive brain stimulation for fatigue in multiple sclerosis patients: A systematic review and meta-analysis.(https://pubmed.ncbi.nlm.nih.gov/31491....

17. Loy, B. D et al (2017). Relationship between perceived fatigue and performance fatigability in people with multiple sclerosis: A systematic review and meta-analysis. (https://pubmed.ncbi.nlm.nih.gov/28789....

18. Nagaraj, K., et al (2013). Prevalence of fatigue in patients with multiple sclerosis and its effect on the quality of life.(https://www.ncbi.nlm.nih.gov/pmc/arti....

19. Patejdl, R.,et al. (2016). Multiple sclerosis and fatigue: A review on the contribution of inflammation and immune-mediated neurodegeneration.(https://pubmed.ncbi.nlm.nih.gov/26589....

20. Patejdl, R., & Zettl, U. K. (2022). The pathophysiology of motor fatigue and fatigability in multiple sclerosis. (https://pubmed.ncbi.nlm.nih.gov/35968....

21. Torres-Costoso, A.,et al (2022). Effect of Exercise on Fatigue in Multiple Sclerosis: A Network Meta-analysis Comparing Different Types of Exercise. (https://pubmed.ncbi.nlm.nih.gov/34509....

22. Yang, T. T., et al (2017). Pharmacological treatments for fatigue in patients with multiple sclerosis: A systematic review and meta-analysis. (https://pubmed.ncbi.nlm.nih.gov/28870....

23. Zimek, D., et al (2023). Overview of the Current Pathophysiology of Fatigue in Multiple Sclerosis, Its Diagnosis and Treatment Options - Review Article. (https://pubmed.ncbi.nlm.nih.gov/38029....

24. Zhou, X.,et al (2022). Clinical application of transcranial magnetic stimulation in multiple sclerosis. (https://www.ncbi.nlm.nih.gov/pmc/arti....

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