Antidepressant Insights | TRC Healthcare Medication Talk Podcast

Listen in as our expert panel discusses practical considerations for starting and optimizing antidepressants for treating depression and anxiety. You’ll listen to panelists cover various aspects of antidepressant use, such as serotonin syndrome, QT prolongation, and weight gain concerns.

Special guests:

Tammie Lee Demler, BS, PharmD, MBA, BCGP, BCPP
Director of Pharmacy and Residency Programs, New York State Office of Mental Health
State University of New York at Buffalo School of Pharmacy and Pharmaceutical Sciences

Sarah E. Grady, PharmD, BCPS, BCPP
Professor, Drake University College of Pharmacy and Health Sciences
Clinical Pharmacist, Inpatient Behavioral Health Unit, Broadlawns Medical Center

You’ll also hear practical advice from TRC’s Editorial Advisory Board member:

Craig D. Williams, PharmD, FNLA, BCPS
Clinical Professor of Pharmacy Practice
Oregon Health and Science University

None of the speakers have anything to disclose.

This podcast is an excerpt from one of TRC’s monthly live CE webinars, the full webinar originally aired in May 2025.

TRC Healthcare offers CE credit for this podcast. Log in to your Pharmacist’s Letter, Pharmacy Technician’s Letter, or Prescriber Insights account and look for the title of this podcast in the list of available CE courses. https://trchealthcare.com/login/

Claim Credit: https://learning.therapeuticresearch....

The clinical resources related to this podcast are part of a subscription to Pharmacist’s Letter, Pharmacy Technician’s Letter, and Prescriber Insights.

Clinical Resources:

Choosing Antidepressants: https://learning.therapeuticresearch....
Switching Antidepressants: https://learning.therapeuticresearch....
Combining and Augmenting Antidepressants: https://learning.therapeuticresearch....
Pharmacotherapy of Anxiety Disorders in Adults: https://learning.therapeuticresearch....

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00:00 - Introduction
02:06 - CE Information
02:38 - Evaluating Antidepressant Options
05:17 - Starting an Antidepressant
11:45 - Serotonin Syndrome
16:39 - QT Prolongation
20:10 - Hyponatremia / Low Sodium
21:09 - Seizure Risk / Bupropion
22:12 - Weight Gain
24:21 - Optimizing Treatment
30:38 - Duration of Treatment
35:02 - PRN Antidepressants
37:09 - Conclusion