Ketamine: How It Rewires Your Brain in Hours | Don't Look Up

Ketamine has been called everything from a battlefield anesthetic to a party drug—but what most people don’t know is how profoundly it can shape neuroplasticity, emotional healing, and nervous system regulation.

In this episode of Don’t Look Up, Boomer Anderson and Dr. Scott Sherr unpack the real science behind ketamine’s psychoplastogenic effects, why it’s emerging as a key tool in the third wave of psychedelics, and how it’s being used safely in medical and therapeutic contexts today.

You’ll learn how:
• Ketamine interacts with glutamate and NMDA receptors
• Why it boosts BDNF and synaptogenesis, and how downregulating the Default Mode Network (DMN) can open a therapeutic window for emotional processing, trauma resolution, and super-learning
• To explore the risks, from tolerance to addiction potential, and the non-negotiables for safe treatment, including proper dosing, integration, and choosing the right clinic

Whether you’re curious about ketamine therapy for treatment-resistant depression, anxious about the “K-hole,” or simply want a science-backed breakdown of how this molecule works, this episode gives you a candid, grounded look at one of the most intriguing tools in modern health optimization.


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Video Chapters:

00:00 Intro: The Third Wave of Psychedelics & Why Ketamine Matters
00:26 What Makes Ketamine Psychoplastogenic
01:13 Ketamine’s Medical Background & Safety Profile
02:26 How Ketamine Works: Glutamate, NMDA & AMPA
04:58 BDNF, Synaptogenesis & Rewiring the Brain
06:10 Ketamine as Party Drug vs Therapeutic Tool
07:21 The “Fresh Snow” Metaphor for Laying New Neural Tracks
08:04 Default Mode Network, Ego & Entering the K-Hole
10:11 IV vs Oral Ketamine: Dosing & Experience
11:48 Ketamine for Treatment-Resistant Depression & Anxiety
14:02 Boomer’s Protocol: Using Ketamine for Anxiety & Super-Learning
16:54 Trauma Processing & Emotional Integration
17:51 Ketamine for Chronic Illness & Nervous System Reset
19:01 How to Choose a Safe, Integrative Ketamine Clinic
20:07 Risks, Addiction Potential & Who Should Avoid Ketamine
24:19 Final Takeaways: Ketamine as a Psychoplastogenic Tool