SAR of Local Anaesthetics | Medicinal Chemistry | Safalta Series | GPAT | NIPER JEE

🧠 Welcome to the Safalta Series by Pharmaminds!
In this power-packed Medicinal Chemistry session, we decode the Structure–Activity Relationship (SAR) of Local Anaesthetics — one of the most conceptual and high-weightage topics for GPAT & NIPER JEE.

Understand how structure governs action, why some agents are ester-based while others are amide-based, and how lipophilicity, hydrophilicity, and ionization balance determine potency, onset, and duration.

📘 What You’ll Learn in This Video:

🔹 General structure and ideal features of local anaesthetics
🔹 Role of the aromatic ring (lipophilic part) in membrane penetration
🔹 Importance of the intermediate linkage (Ester vs Amide) in metabolism and stability
🔹 Function of the amine group (hydrophilic part) in receptor binding and ionization
🔹 SAR variations and their effect on potency, duration, and toxicity
🔹 Comparison between Ester-type (Procaine, Benzocaine) and Amide-type (Lidocaine, Bupivacaine) agents
🔹 Concept of Tertiary vs Secondary amines and Substituent effects
🔹 GPAT/NIPER-focused MCQ insights and exam tricks

🎓 Perfect For:

GPAT 2026 & NIPER JEE Aspirants

Drug Inspector & Pharmacist Exam Candidates

B.Pharm & M.Pharm Students revising Medicinal Chemistry

📚 More from the Safalta Series:

💊 SAR of Sulphonamides: [link]

🧪 Organic Chemistry:    • Inductive Effect| Organic Chemistry 1 | Sa...  

⚖️ Pharmaceutical Jurisprudence:    • Regulatory Bodies and Climatic Zone | Juri...  

💉 Pharmacology:    • First Pass Metabolism | Pharmacology 2 | S...  

🌿 Pharmacognosy:    • Ash value | Pharmacognosy 1 | Safalta Seri...  

💊 Pharmaceutics Playlist:    • SAFALTA SERIES I PHARMACEUTICS  

🎯 PharmaMinds Courses for GPAT & NIPER 2026–2027

1️⃣ Sankalp 2026:
https://bumsi.courses.store/478829

2️⃣ Sankalp 2027:
https://bumsi.courses.store/655840

3️⃣ Sankalp 2026 Plus:
https://bumsi.courses.store/655839

📞 Contact Us:
9315666919 | 8851650388

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