Neutrality tests by Wolfgang Stephan

Second Bangalore School on Population Genetics and Evolution

URL: http://www.icts.res.in/program/popgen...

DESCRIPTION:
Just as evolution is central to our understanding of biology, population genetics theory provides the basic framework to comprehend evolutionary processes. Population genetics theory allows quantitative predictions of evolutionary processes, integrating mathematical and statistical concepts with fundamental biological principles of genetic inheritance and processes such as mutation and selection. Population genetics theory is thus critical to understanding many pressing issues in biology, such as the evolution of antibiotic resistance in pathogens, the formation of new species and the emergence of cooperative and altruistic behaviors.

This school aims to expose students and researchers from diverse backgrounds to the basics and the forefront of current research in population genetics. Students from the disciplines of biology, mathematics, medicine, physics, and statistics who are interested in evolutionary theory are all welcome to apply for participation in this program. The school will introduce and develop an understanding of population genetics and quantitative genetics, and their applications. Research seminars and poster sessions will also be held during this school.

ORGANIZERS: Deepa Agashe, Kavita Jain

Table of Contents (powered by https://videoken.com)
0:00:00 INTERNATIONAL
0:00:06 Neutrality tests
0:00:10 Testing of selective sweep model
1:05:16 Two-locus model of genetic hitchhiking
1:05:33 Heterozygous
1:10:17 Expected hitchhiking effect of a beneficial mutation
1:10:27 Composite-likelihood ratio test (Kim and Stephan 2002)
1:13:09 Total length/height reveals the star-like genealogies
1:17:34 LI and Stephan 2006 Thornton and Arsolfatto 2006 Standard neutral
1:20:10 Spatial modification of SFS after a selective sweep
1:23:15 LD during a selective sweep
1:23:21 In a selective sweep both test statistics point to the same position
1:23:26 Summary statistics of genetic polymorphism
1:25:33 AF EU