Ben Fabry - Universal scaling laws in cell and tissue rheology
Автор: Theory of Living Matter Group - Cambridge U
Загружено: 2025-12-16
Просмотров: 14
Cells and tissues are visco-elastic. Upon mechanical deformation, the dominant part of the deformation energy is elastically stored, and a smaller part is dissipated. This behaviour is captured by a frequency-dependent storage modulus (G’) and loss modulus (G’’), and is traditionally modelled by mechanical networks of elastic springs and viscous elements (“dashpots”). However, such mechanical networks fail to capture the underlying mechanism of energy dissipation. Moreover, the experimentally measured network parameters are physically meaningless, as they depend strongly on the time or frequency range of the experiment. I will show that cells and tissue exhibit a universal power-law scaling of the elastic and dissipative properties that is captured by only two parameters - elasticity and fluidity. Both are strongly coupled through the power-law exponent of the time or frequency dependence, which is the central mechanism by which cells change and adapt their mechanical properties. These experimental findings suggest that cells and tissues behave as a glassy material close to a glass transition, whereby the power-law exponent captures the metastability of the elastic bonds in the material.
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