Computational bio-imaging via inverse scattering

Welcome to the LIBREhub Seminars

“Computational bio-imaging via inverse scattering"

By
Shwetadwip Chowdhury.
Assistant Professor, University of Texas.


Overview
Optical imaging is a major research tool in the basic sciences, and is the only imaging modality that routinely enables non-ionized imaging with subcellular spatial resolutions and high imaging speeds. In biological imaging applications, however, optical imaging is limited by tissue scattering to short imaging depths. This prevents large-scale bio-imaging by allowing visualization of only the outer superficial layers of an organism, or specific components isolated from within the organism and prepared in-vitro.

I present recent developments in our lab that design inverse-scattering methods to computationally unscramble scattering effects and reconstruct 3D refractive-index (RI) in optically thick samples. I will specifically discuss 1) novel computational microscope systems that enable high-NA, coded illumination for collecting a sample’s multiplexed scattering information; and 2) the design and practical implementation of large-scale computational nonlinear and nonconvex frameworks that enable robust RI reconstruction based on correlation analysis, digital refocusing, and low-rank initialization. Real-world bio-imaging will be demonstrated on multiple-scattering organisms popularly used in the basic-sciences. I will also discuss future research directions that can capitalize and extend these developments towards non-optical imaging, which may extend the utility of these computational frameworks to other regimes.




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LIBREhub seminar series bring and connect international speakers with the Latin American bioimaging community through a wide range of topics related to bioimaging technologies. These seminars are part of the LIBREhub training program for open-source bioimaging hardware.
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The Latin American Hub for Bioimaging Through Open Hardware (LIBREhub) is a training network for open source bioimaging hardware in Latin America with the goal to empower regional researchers through practical workshops, seminars, networking, and online resources adapted to local needs and re-published in local languages.

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