What Is The Complement System In Neuromyelitis Optica (NMO)? - MS Support Network

What Is The Complement System In Neuromyelitis Optica (NMO)? Have you ever wondered how the immune system can sometimes mistakenly attack the body’s own nervous tissue? In this video, we explain the role of the complement system in Neuromyelitis Optica (NMO), a condition where the immune response causes significant nerve damage. We’ll cover how autoantibodies target specific water channels in the central nervous system, leading to a cascade of immune reactions. You’ll learn about the activation of the complement pathway, the formation of damaging structures like the membrane attack complex, and how these processes result in the destruction of supportive cells called astrocytes. We’ll also discuss how this cell damage triggers secondary effects, including nerve fiber damage and inflammation, which contribute to the symptoms experienced by individuals with NMO. Additionally, we’ll highlight current treatments that inhibit complement activation, such as eculizumab, and the importance of understanding these mechanisms for accurate diagnosis and effective management. Whether you’re a patient, caregiver, or healthcare professional, understanding the immune processes involved in NMO can help you better grasp the disease and the latest therapeutic options. Join us to learn more about this complex immune response and stay informed about advances in NMO treatment. Don’t forget to subscribe for more health insights.

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