Blood Transfusions | Clinical Medicine

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Ninja Nerds!
In this extensive lecture, Professor Zach Murphy delves into the topic of blood transfusions, starting with the basics of whole blood and breaking it down into its components like packed red blood cells (PRBCs), platelets, fresh frozen plasma (FFP), cryoprecipitate, and prothrombin complex concentrate (PCC). He explains in detail the indications for each type of blood product based on various clinical scenarios such as anemia, hemorrhagic shock, coagulopathies, and thrombocytopenia. The lecture then explores transfusion reactions, including febrile non-hemolytic reactions, hemolytic reactions (acute and delayed), allergic/anaphylactic reactions, transfusion-related acute lung injury (TRALI), and transfusion-associated circulatory overload (TACO). Finally, the video covers pre-transfusion testing processes, blood product modifications, and the proper response to transfusion reactions. Enjoy the lecture and support us below!

00:00 Lab
00:42 Types of Blood Products
02:06 Packed Red Blood Cells (PRBCs)
05:34 Fresh Frozen Plasma (FFP)
06:46 Platelet Transfusions
11:39 Cryoprecipitate and Prothrombin Complex Concentrate (PCC)
47:05 Managing DIC and Massive Bleeding
47:34 Cryoprecipitate and Its Uses
48:30 Blood Product Modifications: Irradiation
53:21 Leuko Reduction: Reducing White Blood Cells
57:56 Washing Blood Products: Reducing Proteins and Potassium
01:01:32 Pre-Transfusion Testing: Type and Screen vs. Type and Cross
01:14:24 Acute Transfusion Complications: Fever and Hemolysis
01:36:32 Managing Acute Hemolytic Reactions
01:37:41 Understanding Allergic and Anaphylactic Reactions
01:53:43 Transfusion-Related Acute Lung Injury (TRALI)
02:04:24 Transfusion-Associated Circulatory Overload (TACO)
02:13:23 Massive Transfusion Protocols and Complications
02:21:10 Sequential Algorithm for Transfusion Needs

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