HRT and Cancer Risk: Reviewing the 2025 Study You’ve Heard About

In this video, Dr. Doug Lucas discusses the relationship between hormone replacement therapy (HRT) and cancer risk, particularly focusing on estrogen and progesterone. He reviews recent literature, including a 2025 paper that raises concerns about micronized progesterone and progestins. Dr. Doug emphasizes the importance of distinguishing between these two forms of progesterone and presents various studies, including the Women's Health Initiative and the PEPI trial, to analyze their implications on cancer risk. He concludes that while there are risks associated with HRT, micronized progesterone does not appear to significantly increase breast cancer risk, advocating for a careful risk-benefit analysis in treatment decisions.

STUDIES
https://www.annalsofoncology.org/arti...
https://pubmed.ncbi.nlm.nih.gov/24781...
https://jamanetwork.com/journals/jama...
https://academic.oup.com/jnci/article...
https://www.tandfonline.com/doi/abs/1...

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This channel is focused on Bones, Hormones, and Healthspan to help midlife women and beyond aim for optimal, not average, and reignite their spark!

The videos on this channel will be focused around helping women navigate healthspan and longevity through the lens of osteoporosis, perimenopause, and menopause. When it comes to osteoporosis and menopause providers and educators often get tunnel vision and your symptoms might get better, but if you don't keep longevity in mind, symptom improvement may come at the expense of heart and brain health.

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ABOUT DR. DOUG LUCAS

Dr. Doug Lucas is the VP of Women’s Health, Hormone and Lifestyle Optimization at LifeMD and founder of The OsteoCollective. Dr. Doug is on a mission to educate the world that osteoporosis is preventable and in many cases reversible! He will change the conversion around bone health from a disease of the elderly to bone health as a biomarker of healthspan.


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Watch and Enjoy! Dr. Doug Lucas Key Moments in this Episode
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Chapters

00:00 Understanding Hormone Replacement Therapy and Cancer Risks
02:46 The Role of Estrogen in Cancer Development
06:03 Progestins vs. Micronized Progesterone: A Comparative Analysis
08:50 Evaluating Studies on Micronized Progesterone and Cancer Risk
12:07 Insights from the PEPI Trial and Other Research
14:54 The French Cohort Study: Findings on Micronized Progesterone
17:48 Risk-Benefit Analysis of Hormone Replacement Therapy