GCE4All Research Center
The GCE4All Center: Unleashing the Potential of Genetic Code Expansion for Biomedical Research (GCE4All) is a Biomedical Technology Development and Dissemination (BTDD) Center supported by Oregon State University and grant RM1-GM144227 from the National Institute of General Medical Sciences of the National Institutes of Health.
Genetic Code Expansion (GCE) is a powerful tool with vast implications for basic research and the development of new therapeutics. By optimizing, developing and broadly disseminating GCE technologies, the GCE4All Center makes the use of powerful tools and approaches standard; enabling scientific breakthroughs worldwide.
Main-chain hydrogen bonding in GABAA receptor gating and disease
Intracellular Protein Editing
Development of ACE-tRNAs as a Platform Therapeutic: Does Nonsense to Missense Make Sense?
Tools to Decode Molecular Plasticity in the Dark Proteome
Leveraging Genetic Code Expansion to Better Understand a Neurodevelopmental Disorder
A Dual-Purpose ncAA for the Expanded Genetic Code: Combining Metal-Binding and Click Chemistry
Fluorescence labelling of re-coded E.coli w/ non-canonical chem. entities for single mol. tracking
Small Molecule Approaches to Mediate Nonsense Suppression
Ribosomal Synthesis of Diketone-containing Peptide Backbone via Post-Translational Acyl Shift
GCE enables visualization of Salmonella type three secretion system components & secreted effectors
Investigating site-specific acetylation of ubiquitin & suitability of surrogates by GCE
Studying structural & functional consequences of site-specific phos in Ubiquitin and NEDD8
Unleashing the Potential of Genetic Code Expansion - GCE4All Center
Genetically Encoded Bioorthogonal Chemistry in Living Systems
Applications of Genetic Code Expansion and Bioorthogonal Chemistry to Study Membrane Proteins
Novel molecular insights into the Orai1 channel dynamics using photocrosslinking
Chemically expanded antibody engineering on the yeast surface: covalent antibodies and more
Engineering post-translationally modified selenoproteins in E. coli
The cX-Zyme: A Halogen Bond Catalyzed DNA Nuclease
Expanding the non-canonical amino acid toolbox for mammalian cells
Isotope-labelled, serine16 phosphorylated, amelogenin–the key to brighter smiles
Protein chemistry: an unnatural approach to unravelling the mystery of allostery
Applications of the Fluorescent Amino Acid Acridonylalanine
Split aminoacyl-tRNA synthetases for proximity-induced stop codon suppression
Identification of neuropeptide & toxin binding sites on membrane-embedded receptor via crosslinking
Expanded genetic code for live-cell fluorescent protein labeling in (neuro)biology
Engineering Biomaterials Bearing Non-Canonical Amino Acids
Methodological challenges of an expanded genetic code
Decoding the Language of Aromatic Side-Chains in Ion Channels and Receptors
Investigations of multi-domain DNA/RNA binding protein machines using FEncAA