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Split aminoacyl-tRNA synthetases for proximity-induced stop codon suppression
Автор: GCE4All Research Center
Загружено: 2023-04-20
Просмотров: 257
Описание:
Talk given by Jeffery M. Tharp (Indiana University School of Medicine) as part of the International GCE Webinar series. Live talk given on April 20th, 2023.
The ability to control gene expression in living cells has many useful applications in biotechnology and medicine. In this talk I will describe the design and engineering of split orthogonal aminoacyl-tRNA synthetases (o-aaRSs) that can be used to tightly control gene expression in bacteria and in human cells. Furthermore, I will describe how these split o-aaRSs can serve as useful tools for detecting protein–protein interactions, including those involved human disease.
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