The Evolution Revolution: Scouting Frontiers in AI for Biology with Brian Hie

In this episode of The Cognitive Revolution, Nathan explores the cutting-edge intersection of AI and biology with Stanford assistant professor Brian Hie. Discover how AI is revolutionizing our understanding of biological systems and creating new possibilities for interventions. Brian discusses his groundbreaking papers on hybrid AI architectures, the surprising capabilities of language models trained on DNA sequences, and AI-guided evolution of antibodies. Join us for an insightful journey into the future of AI in biology, touching on biosecurity, drug discovery, and the challenges of interpreting AI models in biological contexts.

Links :
Brian Hie: https://x.com/BrianHie
Scanorama paper: https://www.nature.com/articles/s4159...
Mechanistic Design and Scaling of Hybrid Architectures: https://arxiv.org/pdf/2403.17844
Sequence modeling and design from molecular to genome scale with Evo: https://www.biorxiv.org/content/10.11...
Unsupervised evolution of protein and antibody complexes with a structure-informed language model : https://static1.squarespace.com/stati...

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CHAPTERS:
(00:00:00) About the Show
(00:00:22) About the Episode
(00:03:22) Introduction and Overview
(00:03:55) AI for Biology: Big Picture
(00:05:49) Challenges in Biology and Drug Discovery
(00:08:36) Scanorama and Single Cell Transcriptomics
(00:10:27) Brian's Research Identity
(00:13:00) Mechanistic Design of Hybrid Architectures
(00:14:52) Evo: DNA Language Model (Part 1)
(00:18:10) Sponsors: 80,000 Hours | Brave
(00:20:44) Evo: DNA Language Model (Part 2)
(00:28:58) Gene Essentiality and Evo's Capabilities
(00:29:19) Unsupervised Evolution of Protein Complexes (Part 1)
(00:31:02) Sponsors: Omneky | Oracle
(00:32:24) Unsupervised Evolution of Protein Complexes (Part 2)
(01:10:27) Improving Antibody Binding Affinity
(01:14:24) Overfitting and ARC Institute
(01:18:11) Outro

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