New Brain Research Links Anxiety to Low Choline

New research shows people with anxiety have lower choline in the brain. What choline does and is choline a good supplement for anxiety

The original study: https://www.nature.com/articles/s4138...
another analysis: https://pubmed.ncbi.nlm.nih.gov/19656...
see our website for full list of articles referenced

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New neuroscience research suggests that people with anxiety disorders have lower levels of choline in the brain compared to those without anxiety. In this video I explain what choline is, how it supports acetylcholine and the nervous system, and what this study does—and does not—mean for anxiety.
Anxiety isn’t just a mindset problem. It’s a whole-body nervous system state, and the brain is a physical organ that depends on nutrients to function well. We’ll look at the study published in Molecular Psychiatry, how researchers measured brain chemistry using ¹H-MRS imaging, and why lower choline may make it harder for the nervous system to shift out of fight-or-flight.
This video is not about magical supplements or quick fixes. The research is early, correlational, and choline is not a cure for anxiety. We’ll also talk about what we do know helps anxiety long-term: sleep, movement, nutrition, therapy skills, and nervous system regulation.
You’ll learn:
What choline does in the brain
How acetylcholine supports calm and regulation
Whether low choline causes anxiety (or not)
What the research actually says about supplementation
Practical, grounded ways to support your mental health ecosystem

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Therapy in a Nutshell and the information provided by Emma McAdam are solely intended for informational and entertainment purposes and are not a substitute for advice, diagnosis, or treatment regarding medical or mental health conditions. Although Emma McAdam is a licensed marriage and family therapist, the views expressed on this site or any related content should not be taken for medical or psychiatric advice. Always consult your physician before making any decisions related to your physical or mental health.
In therapy I use a combination of Acceptance and Commitment Therapy, Systems Theory, positive psychology, and a bio-psycho-social approach to treating mental illness and other challenges we all face in life. The ideas from my videos are frequently adapted from multiple sources. Many of them come from Acceptance and Commitment Therapy, especially the work of Steven Hayes, Jason Luoma, and Russ Harris. The sections on stress and the mind-body connection derive from the work of Stephen Porges (the Polyvagal theory), Peter Levine (Somatic Experiencing) Francine Shapiro (EMDR), and Bessel Van Der Kolk. I also rely heavily on the work of the Arbinger institute for my overall understanding of our ability to choose our life's direction.
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